📚 Main Topics

1. Skepticism about NAD Supplements

   • The speaker expresses previous skepticism regarding NAD supplements but acknowledges new research suggesting potential benefits against Alzheimer's disease.

2. NAD and Alzheimer's Disease

   • Alzheimer's disease is characterized by a low NAD to NADH ratio, which is linked to various cellular dysfunctions.
   • NAD is crucial for DNA repair, glucose metabolism, neurogenesis, and synaptic plasticity.

3. Recent Study Findings

   • A major study indicates that boosting NAD levels in the brain can reverse DNA damage and improve memory function in animal models of Alzheimer's.
   • The study shows promising results, suggesting a complete reversal of Alzheimer's symptoms in the model used.

4. NAD Boosting Alternatives

   • Direct NAD injections are not available; however, precursor supplements like nicotinamide and nicotinamide mononucleotide can potentially boost NAD levels.
   • Previous human studies on NAD precursors have shown weak results, but new mechanistic evidence supports their potential against Alzheimer's.

5. Clinical Trials and Limitations

   • Three clinical trials on NAD boosting showed no significant effects on Alzheimer's disease, leading to a reconsideration of NAD precursors.
   • The speaker introduces medium-chain triglycerides (MCTs) as an alternative that has shown promise in raising brain NAD levels and improving cognitive function.

6. MCTs and Alzheimer's Disease

   • Studies indicate that MCT supplementation can improve cognitive function in individuals at risk for Alzheimer's.
   • The effective dosage of MCTs ranges from 10g to 30g, and while results are promising, they are still considered mild.

7. Future Directions

   • The potential of ketogenic diets as a means to boost NAD levels is mentioned, though current studies are limited.
   • The speaker plans to revisit the topic in future discussions.

✨ Key Takeaways

• NAD plays a critical role in brain health, and its deficiency is linked to Alzheimer's disease.
• Boosting NAD levels can reverse some cellular damage associated with Alzheimer's.
• MCTs may offer a viable alternative for improving cognitive function and raising NAD levels in the brain.
• Current research on NAD supplements is inconclusive, but emerging evidence on MCTs is encouraging.

🧠 Lessons

• Skepticism in science is important, but new evidence can shift perspectives.
• Understanding the mechanisms behind supplements is crucial for evaluating their effectiveness.
• Alternative nutritional strategies, such as MCT supplementation, may provide unexpected benefits in combating diseases like Alzheimer's.
• Continuous research and open-mindedness are essential in the pursuit of effective treatments for complex conditions.