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Ep. 9: Is Histamine Causing Your Acid Reflux? | GERD, MCAS & Low Stomach Acid Explained

by Molly Pelletier, MS, RD | Acid Reflux Dietitian

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📚 Episode Overview

In this episode of the Reflux Revolution Podcast, host Molly Peliter, a registered dietitian and founder of Flora Nutrition, discusses various controversial topics related to gastroesophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) with Dr. Zachary Spirittos, a specialist in neurogastroenterology. They explore the root causes of reflux, including low stomach acid, histamine issues, mast cell activation syndrome (MCAS), and hypermobility.

📚 Main Topics

  1. Understanding Reflux

    • Definition of GERD and LPR.
    • Symptoms include heartburn, regurgitation, chronic throat clearing, and dry cough.
  2. Low Stomach Acid and Reflux

    • Discussion on whether low stomach acid causes reflux.
    • Clarification that low acid states do not typically cause reflux symptoms.
  3. Digestive Enzymes and Reflux

    • Insights on why digestive enzymes may work for some individuals, particularly those with gastroparesis.
  4. Common Overlooked Drivers of Reflux

    • Obesity and its impact on the lower esophageal sphincter.
    • Hiatal hernias and their mechanical effects on reflux.
  5. Functional Reflux and Chest Pain

    • Differentiating between structural and functional causes of reflux.
    • The role of the brain-gut interaction in functional reflux.
  6. Hypermobility Syndromes and GI Issues

    • Connection between hypermobility and gastrointestinal motility issues.
    • Unique challenges faced by individuals with hypermobility.
  7. Histamine and Mast Cell Activation

    • Explanation of how histamine affects acid secretion and contributes to reflux symptoms.
    • Differences between histamine intolerance and mast cell activation syndrome.
  8. Assessment and Management Strategies

    • Importance of identifying triggers for histamine issues and MCAS.
    • Recommendations for dietary changes and medication options.

✨ Key Takeaways

  • Low stomach acid is not a common cause of reflux symptoms; rather, it can lead to different gastrointestinal issues.
  • Obesity and hiatal hernias are significant contributors to reflux that are often overlooked.
  • Functional reflux may stem from a hypersensitive nervous system rather than structural issues.
  • Individuals with hypermobility may experience a range of GI symptoms due to connective tissue issues.
  • Histamine intolerance and MCAS can manifest with reflux-like symptoms but require different management strategies.

🧠 Lessons Learned

  • A personalized approach to managing reflux is essential, as each individual's experience and underlying causes may differ.
  • Collaboration between patients and healthcare providers is crucial for effective management of complex conditions like MCAS and hypermobility syndromes.
  • Keeping a symptom diary can help identify triggers and improve management strategies for those with histamine-related issues.

🏁 Conclusion

This episode provides valuable insights into the complexities of reflux and related conditions, emphasizing the importance of understanding individual symptoms and working closely with healthcare professionals for effective management. For more information, listeners are encouraged to follow Dr. Zachary Spirittos on Instagram and explore his clinic, Ever Better Medicine.

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